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15-Lipoxygenase Inhibitor 1
CAS No. 928853-86-5
15-Lipoxygenase Inhibitor 1 ( 4-MMPB )
产品货号. M24982 CAS No. 928853-86-5
15-Lipoxygenase Inhibitor 1 是 15-lipoxygenase 的选择性抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1393 | 有现货 |
|
| 10MG | ￥2341 | 有现货 |
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| 25MG | ￥4358 | 有现货 |
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| 50MG | ￥6302 | 有现货 |
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| 100MG | ￥8829 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称15-Lipoxygenase Inhibitor 1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述15-Lipoxygenase Inhibitor 1 是 15-lipoxygenase 的选择性抑制剂。
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产品描述15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 4-MMPB has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer.(In Vitro):4-MMPB has an IC50 of 69.6 μM for DPPH bleaching.4-MMPB exhibits cytotoxic activity on human PC-3 and HFF3 cell lines.4-MMPB (41.48 μM; 72 hours) induces apoptosis and DNA damage in PC-3 Cells.
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体外实验4-MMPB has an IC50 of 69.6 μM for DPPH bleaching.4-MMPB exhibits cytotoxic activity on human PC-3 and HFF3 cell lines.4-MMPB (41.48 μM; 72 hours) induces apoptosis and DNA damage in PC-3 Cells.Cell Viability Assay Cell Line:DU145 cells, PC-3 cells, HFF3 cells Concentration:9.57 μM, 19.94 μM, 39.88 μM, 79.77 μM,159.53 μM Incubation Time:24 hours, 48 hours, 72 hours Result:Inhibited cells viability (IC50=79.76 μM; 24 h, 51.05 μM; 48 h, 41.48 μM; 72 h for PC-3 cells, IC50=255.25 μM; 24 h, 130.81 μM; 48 h, 98.91 μM; 72 h for HFF3 cells).
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体内实验——
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同义词4-MMPB
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number928853-86-5
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分子量313.4
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分子式C16H19N5S
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纯度>98% (HPLC)
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溶解度DMSO:8mg/mL (25.52mM)
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SMILESCC1=C2C(=NC(=N1)N3CCN(CC3)C)SC4=CC=CC=C4N2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Nikpour M , Mousavian M , Mahdieh Davoodnejad…. Synthesis of new series of pyrimido[4,5- b ][1,4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanism[J]. Medicinal Chemistry Research, 2013, 22(10):5036-5043.
